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材料工程  2017, Vol. 45 Issue (4): 113-120    DOI: 10.11868/j.issn.1001-4381.2016.000319
  研究论文 本期目录 | 过刊浏览 | 高级检索 |
沉淀法与水热法合成载银羟基磷灰石及其抗菌性能
邓城, 漆小鹏, 李倩, 尹从岭, 杨辉
江西理工大学 材料科学与工程学院, 江西 赣州 341000
Synthesis and Antibacterial Property of Silver Doped Hydroxyapatite by Precipitation and Hydrothermal Method
DENG Cheng, QI Xiao-peng, LI Qian, YIN Cong-ling, YANG Hui
School of Material Science and Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, Jiangxi, China
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摘要 采用沉淀法与水热法合成了纳米棒状载银羟基磷灰石(Ag-HA)颗粒。研究不同合成方法和载银量时Ag-HA晶体结构、形貌及抗菌性能。结果表明:水热法合成的Ag-HA长径比高、分散性好,产物结晶度高、晶粒尺寸大,晶胞参数更小。沉淀法70℃时,Ag-HA平均晶粒尺寸为(22.7±0.7)nm;水热法180℃时,平均晶粒尺寸为(50.7±0.9)nm。银的引入会增大产物晶粒尺寸及晶胞参数,当载银量为1.30%时,平均晶粒尺寸为(53.7±0.9)nm,晶胞参数a=0.9465nm,c=0.6970nm。产物与大肠杆菌(E.coli)和金黄色葡萄球菌(S.aureus)共培养后结果显示,Ag-HA对两种实验菌均表现出良好的杀菌性能,不同载银量Ag-HA在1,3,6,12,24h后的杀菌率均为100%。
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邓城
漆小鹏
李倩
尹从岭
杨辉
关键词 载银羟基磷灰石沉淀法水热法晶体结构抗菌性能    
Abstract:Nanorod Ag doped hydroxyapatites (Ag-HA) were synthesized by precipitation and hydrothermal method. Crystal structure, morphology and antibacterial property of prepared samples with silver contents prepared by different synthesis methods were investigated. The results show that Ag doped hydroxyapatites synthesized by hydrothermal method possess a higher length to diameter ratio, higher degree of crystallinity, better dispersion,larger grain size and smaller unit cell parameters. The average crystal size of prepared samples by precipitation method at 70℃ and hydrothermal method at 180℃ are (22.7±0.7)nm and (50.7±0.9)nm, respectively. In addition, adding silver into hydroxyapatite may increase grain size and unit cell parameters. When silver content is 1.30%, average grain size and unit cell parameters are (53.7±0.9)nm and a =0.9465nm, c =0.6970nm, respectively. Antibacterial test results indicate that Ag-HA exhibits good bactericidal property against Escherichia coli ( E.coli ) and Staphylococcus aureus ( S.aureus ). The antibacterial rate is 100% when silver content varies after different hours(1, 3, 6, 12, 24h).
Key wordsAg-HA    precipitation method    hydrothermal method    crystal structure    antibacterial property
收稿日期: 2016-03-19      出版日期: 2017-04-17
中图分类号:  TB34  
通讯作者: 漆小鹏(1977-),男,副教授,博士,主要从事无机非金属材料及生物功能材料的研究,联系地址:江西省赣州市客家大道156号江西理工大学材料科学与工程学院(341000),E-mail:qxpai@163.com     E-mail: qxpai@163.com
引用本文:   
邓城, 漆小鹏, 李倩, 尹从岭, 杨辉. 沉淀法与水热法合成载银羟基磷灰石及其抗菌性能[J]. 材料工程, 2017, 45(4): 113-120.
DENG Cheng, QI Xiao-peng, LI Qian, YIN Cong-ling, YANG Hui. Synthesis and Antibacterial Property of Silver Doped Hydroxyapatite by Precipitation and Hydrothermal Method. Journal of Materials Engineering, 2017, 45(4): 113-120.
链接本文:  
http://jme.biam.ac.cn/CN/10.11868/j.issn.1001-4381.2016.000319      或      http://jme.biam.ac.cn/CN/Y2017/V45/I4/113
[1] HENCH L L.Bioceramics[J].Journal of the American Ceramic Society,1998,81(7):1705-1728.
[2] 肖镇昆,吴磊,米饶,等.碳纳米管对羟基磷灰石基复合材料力学性能的影响[J].无机化学学报,2015,31(1):114-120. XIAO Z K,WU L,MI R,et al.Effect of carbon nanotubes on the mechanical properties of carbon nanotubes/hydroxyapatite composites[J].Chinese Journal of Inorganic Chemistry,2015,31(1):114-120.
[3] 刘翠莲,唐春康.骨及生物材料中的纳米磷酸钙[J].无机化学学报,2014,30(1):1-9. LIU C L,TANG C K.Calcium phosphate nanoparticles in bone and biomaterials[J].Chinese Journal of Inorganic Chemistry,2014,30(1):1-9.
[4] RAMESHBABU N,SAMPATH K T S,PRABHAKAR T G,et al.Antibacterial nanosized silver substituted hydroxyapatite:synthesis and characterization[J].Journal of Biomedical Materials Research Part A,2007,80(3):581-591.
[5] STANIC V,JANACKOVIC D,DIMITRIJEVIC S,et al.Synthesis of antimicrobial monophase silver-doped hydroxyapatite nanopowders for bone tissue engineering[J].Applied Surface Science,2011,257(9):4510-4518.
[6] 卢志华,孙康宁.载银羟基磷灰石的制备与表征[J].稀有金属材料工程,2009,38(增刊1):56-60. LU Z H,SUN K N.Preparation and characterization of silver loaded hydroxyapatite[J].Rare Metal Materials and Engineering,2009,38(Suppl 1):56-60.
[7] IVASHCHENKO O,PROTSENKO L,BUDYLINA O,et al.Influence of silver doping on hydroxyapatite properties[J].Advanced Science,Engineering and Medicine,2013,5(3):266-274.
[8] LARIMER C,OSTROWSKI N,SPEAKMAN J,et al.The segregation of silver nanoparticles in low-cost ceramic water filters[J].Materials Characterization,2010,61(4):408-412.
[9] DIAZ M,BARBA F,MIRANDA M,et al.Synthesis and antimicrobial activity of a silver-hydroxyapatite nanocomposite[J].Journal of Nanomaterials,2009,2009:1-5.
[10] 夏金兰,王春,刘新星.抗菌剂及其抗菌机理[J].中南大学学报,2004,35(1):31-38. XIA J L,WANG C,LIU X X.Research on antimicrobial agents and their mechanisms of actions[J].Journal of Central South University,2004,35(1):31-38.
[11] PATTABI R M,SRIDHAR K R,GOPAKUMAR S,et al.Antibacterial potential of silver nanoparticles synthesised by electron beam irradiation[J].International Journal of Nanoparticles,2010,3(1):53-64.
[12] SIMON V,ALBON C,SIMON S.Silver release from hydroxyapatite self-assembling calcium-phosphate glasses[J].Journal of Non-Crystalline Solids,2008,354(15):1751-1755.
[13] ASMUS S M F,SAKAKURA S,PEZZOTTI G.Hydroxyapatite toughened by silver inclusions[J].Journal of Composite Materials,2003,37(23):2117-2129.
[14] LIM P N,TEO E Y,HO B,et al.Effect of silver content on the antibacterial and bioactive properties of silver-substituted hydroxyapatite[J].Journal of Biomedical Materials Research Part A,2013,101(9):2456-2464.
[15] CHEN H X,XUE F,YANG D,et al.Hydrothermal synthesis and characterization of Ag-doped hydroxyapatite antibacterial agent[J].Acta Chimica Sinica,2012,70(12):1362-1366.
[16] PRAMANIK S,AGARWAL A K,RAI K N,et al.Development of high strength hydroxyapatite by solid-state-sintering process[J].Ceramics International,2007,33(3):419-426.
[17] CHEN W,OH S,ONG A P,et al.Antibacterial and osteogenic properties of silver-containing hydroxyapatite coatings produced using a sol gel process[J].Journal of Biomedical Materials Research Part A,2007,82(4):899-906.
[18] MONTERO V M,SHI J.Theoretical and experimental study of the incorporation of tobramycin and strontium-ions into hydroxyapatite by means of co-precipitation[J].Applied Surface Science,2014,314(24):376-383.
[19] IQBAL N,KADIR M R A,MALEK N A N N,et al.Rapid microwave assisted synthesis and characterization of nanosized silver-doped hydroxyapatite with antibacterial properties[J].Materials Letters,2012,89(25):118-122.
[20] WANG Z,YAN Y,WAN T.Fabrication and characterization of hydroxyapatite/collagen bone-like nanocomposite through a self-assembly method[J].Science and Engineering of Composite Materials,2012,19(2):177-182.
[21] 杨辉,蔡日强,王栋,等.抗菌羟基磷灰石的一步合成及其表征[J].功能材料,2010,41(3):406-109. YANG H,CAI R Q,WANG D,et al.Preparation and characterization of antibacterial hydroxyapatite powder using one step coprecipitation method[J].Journal of Functional Materials,2010,41(3):406-109.
[22] ZHANG Y,LU J.A mild and efficient biomimetic synthesis of rodlike hydroxyapatite particles with a high aspect ratio using polyvinylpyrrolidone as capping agent[J].Crystal Growth and Design,2008,8(7):2101-2107.
[23] DUBNIKA A,RUDOVICA V.Evaluation of silver ion bioavailability from silver doped hydroxyapatite[J].Key Engineering Materials,2014,604:200-203.
[24] 徐伏秋,陈华军,丁梧秀.载银羟基磷灰石抗菌粉体和陶瓷的制备及抗菌性能[J].无机化学学报,2013,29(12):2582-2586. XU F Q,CHEN H J,DING W X.Preparation and antibacterial property of Ag-doped hydroxyapatite antibacterial powders and antibacterial ceramic[J].Chinese Journal of Inorganic Chemistry,2013,29(12):2582-2586.
[25] BADROUR L,SADEL A,ZAHIR M,et al.Synthesis and physical and chemical characterization of Ca10-xAgx(PO4)6(OH)2-x2 apatites[J].Annales de Chimie Science des Matériaux,1998,23(1-2):61-64.
[26] CAO M,WANG Y,GUO C,et al.Preparation of ultrahigh-aspect-ratio hydroxyapatite nanofibers in reverse micelles under hydrothermal conditions[J].Langmuir,2004,20(11):4784-4786.
[27] 廖建国,刘琼.微波法合成纳米羟基磷灰石晶体及表征[J].稀有金属材料与工程,2014,43(7):1779-1782. LIAO J G,LIU Q.Synthesis of nano-hydroxyapatite by microwave process and its characterization[J].Rare Metal Materials and Engineering,2014,43(7):1779-1782.
[28] RAJENDRAN A,BARIK R C,NATARAJAN D,et al.Synthesis,phase stability of hydroxyapatite-silver composite with antimicrobial activity and cytocompatability[J].Ceramics International,2014,40(7):10831-10838.
[29] ISLAM M S,LARIMER C,OJHA A,et al.Antimycobacterial efficacy of silver nanoparticles as deposited on porous membrane filters[J].Materials Science and Engineering:C,2013,33(8):4575-4581.
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