Abstract：The NiFe2O4 nanoparticles were synthesized by hydrothermal synthesis method. N,O-carboxymethyl chitosan (N,O-CMC) was obtained with chloroacetic acid and chitosan in alkaline condition. Magnetic N,O-carboxymethyl chitosan microspheres (magnetic N,O-CMC microspheres) were prepared by emulsion crosslinking method using carboxymethyl chitosan as matrix material and glutaraldehyde as a crosslinking agent. The compositions, structure, morphology, thermal stability and magnetic property of the materials were characterized by fourier transform infrared spectrometer (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and alternating gradient magnetometer (AGM). The results show that the NiFe2O4 particles have cubic spinel structure, the particle diameter is 10-80nm, saturation magnetization is 43.3A·m2·kg-1. The magnetic N,O-carboxymethyl chitosan microspheres are spherical shape and have smooth surface, the diameter is about 6-25μm, mass fraction of NiFe2O4 nanoparticles in magnetic microspheres is 35.6%, and the saturation magnetization is 14.3A·m2·kg-1.
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