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材料工程  2019, Vol. 47 Issue (12): 124-129    DOI: 10.11868/j.issn.1001-4381.2019.000699
  研究论文 本期目录 | 过刊浏览 | 高级检索 |
快速膨胀海藻酸钠/二氧化硅纤维复合支架的制备及其快速止血功能的应用
舒华金1, 吴春萱2, 杨康3, 刘廷武3, 李晨4, 曹传亮5
1. 南昌大学医院, 南昌 330031;
2. 南昌大学第二临床医学院, 南昌 330006;
3. 南昌大学 药学院, 南昌 330031;
4. 南昌大学第二附属医院, 南昌 330006;
5. 南昌大学 机电工程学院, 南昌 330031
Preparation of rapid expansion alginate/silica fiber composite scaffold and application of rapid hemostatic function
SHU Hua-jin1, WU Chun-xuan2, YANG Kang3, LIU Ting-wu3, LI Chen4, CAO Chuan-liang5
1. Hospital of Nanchang University, Nanchang 330031, China;
2. The Second Clinical Medical School, Nanchang University, Nanchang 330006, China;
3. College of Pharmacy, Nanchang University, Nanchang 330031, China;
4. The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China;
5. School of Mechanical and Electronic Engineering, Nanchang University, Nanchang 330031, China
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摘要 采用静电纺丝技术制备二氧化硅纳米纤维丝,采用梯度冷冻干燥法及钙离子交联,最终得到一种海藻酸钠(ALG)包覆纳米二氧化硅的三维支架,用于止血海绵(ALG/SiO2/Ca2+止血海绵)。通过扫描电镜,细胞实验,体内止血实验,对其结构、组成、细胞毒性、生物相容性以及止血功能进行进一步探究。结果表明:ALG/SiO2/Ca2+止血海绵具有高度疏松的多孔结构,能快速吸水膨胀,浸水10s体积膨胀到原来的219%;细胞实验结果显示该新型止血海绵有很好的细胞相容性;体内止血实验结果显示采用ALG/SiO2/Ca2+止血海绵在10s内完成止血,与医用纱布组相比,出血量显著减少。因此,这种新型止血海绵在深部创口中具备快速吸水膨胀止血并提供伤口湿润环境等优异性能。
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舒华金
吴春萱
杨康
刘廷武
李晨
曹传亮
关键词 二氧化硅纤维静电纺丝止血海绵生物相容性快速膨胀    
Abstract:Silica nanofibers were prepared by electrospinning technique, and then a sodium alginate coated three-dimensional silica hemostatic sponge (ALG/SiO2/Ca2+ sponge) was obtained by freeze-drying method and Ca2+ crosslinking. The structure, composition, cytotoxicity, biocompatibility and hemostatic function were characterized by scanning electron microscopy, cell experiments and in vivo hemostasis experiment. The results show that the ALG/SiO2/Ca2+ hemostatic sponge has a highly porous structure and fast swelling performance. Immersed in water for 10s, the volume expands to 219% compared with the original. The results of cell experiments show that the new hemostatic sponge has good cytocompatibility; the results of in vivo hemostasis show that hemostasis is achieved within 10s using the ALG/SiO2/Ca2+ hemostatic sponge, and the amount of bleeding is significantly reduced compared with medical gauze. Therefore, this new type of hemostatic sponge has excellent properties such as rapid water swelling and hemostasis in the deep wound and providing a moist environment for wound.
Key wordssilica fiber    electrospinning    hemostatic sponge    biocompatibility    rapid swelling
收稿日期: 2019-07-26      出版日期: 2019-12-17
中图分类号:  TB332  
基金资助: 
通讯作者: 曹传亮(1986-),男,讲师,博士,主要研究方向为生物3D打印,联系地址:江西省南昌市红谷滩新区学府大道999号南昌大学机电工程学院(330031),E-mail:cl_cao@ncu.edu.cn     E-mail: cl_cao@ncu.edu.cn
引用本文:   
舒华金, 吴春萱, 杨康, 刘廷武, 李晨, 曹传亮. 快速膨胀海藻酸钠/二氧化硅纤维复合支架的制备及其快速止血功能的应用[J]. 材料工程, 2019, 47(12): 124-129.
SHU Hua-jin, WU Chun-xuan, YANG Kang, LIU Ting-wu, LI Chen, CAO Chuan-liang. Preparation of rapid expansion alginate/silica fiber composite scaffold and application of rapid hemostatic function. Journal of Materials Engineering, 2019, 47(12): 124-129.
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http://jme.biam.ac.cn/CN/10.11868/j.issn.1001-4381.2019.000699      或      http://jme.biam.ac.cn/CN/Y2019/V47/I12/124
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