1 Hospital of Nanchang University, Nanchang 330031, China 2 The Second Clinical Medical School, Nanchang University, Nanchang 330006, China 3 College of Pharmacy, Nanchang University, Nanchang 330031, China 4 The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China 5 School of Mechanical and Electronic Engineering, Nanchang University, Nanchang 330031, China
Silica nanofibers were prepared by electrospinning technique, and then a sodium alginate coated three-dimensional silica hemostatic sponge (ALG/SiO2/Ca2+ sponge) was obtained by freeze-drying method and Ca2+ crosslinking. The structure, composition, cytotoxicity, biocompatibility and hemostatic function were characterized by scanning electron microscopy, cell experiments and in vivo hemostasis experiment. The results show that the ALG/SiO2/Ca2+ hemostatic sponge has a highly porous structure and fast swelling performance. Immersed in water for 10s, the volume expands to 219% compared with the original. The results of cell experiments show that the new hemostatic sponge has good cytocompatibility; the results of in vivo hemostasis show that hemostasis is achieved within 10s using the ALG/SiO2/Ca2+ hemostatic sponge, and the amount of bleeding is significantly reduced compared with medical gauze. Therefore, this new type of hemostatic sponge has excellent properties such as rapid water swelling and hemostasis in the deep wound and providing a moist environment for wound.
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